Extended Data Fig. 4: XMV-Ag induces T-cell immune responses. | Nature Biomedical Engineering

Extended Data Fig. 4: XMV-Ag induces T-cell immune responses.

From: Targeting vaccines to dendritic cells by mimicking the processing and presentation of antigens in xenotransplant rejection

Extended Data Fig. 4

a, Flow cytometry analysis of OVA tetramer+CD8+ T cells in total blood immune cells. b, Percentages of IFN-γ+ cells in splenic CD8+CD44+ T cells from mice treated with three vaccinations of XMV-Ag, AUV-Ag, LIP-Ag, free Ag, or PBS. Representative flow dot plots (c-d) and quantifications (e-f) of memory cells in CD4+ or CD8+ T cells, naive T cells in CD4+ or CD8+ T cells in spleen cells after three-doses of XMV-Ag, AUV-Ag, LIP-Ag, free Ag, or PBS. Data are presented as mean ±s.d.(n = 4), statistical differences were determined using one-way ANOVA with Tukey’s test for multiple comparison.

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