Fig. 3: ASTRA independent validation with the Houston cohort.
From: Self-powered rapid antigen-specific T-cell response assay for Mycobacterium tuberculosis infections
a, Houston cohort (n = 38) HIV status, microbiologic evidence of TB (Xpert, culture) and immunologic evidence of M.tb infection (IGRA) and ASTRA 4-1BB + OX-40 results, in HIV-positive and -negative TB, LTBI and TB suspect cases and healthy control and other disease control groups. b, ASTRA IFNγ and 4-1BB + OX-40 results for HIV-positive and -negative Houston cohort individuals after stimulation with or without (negative control; NC) M.tb peptides or PHA. c, M.tb-peptide-stimulated ASTRA 4-1BB + OX-40 and ASTRA IFNγ PBMC responses for HIV-positive and -negative Houston cohort participants diagnosed with TB or LTBI (n = 16 biological replicates). Bar graphs display mean ± s.d. Dashed red lines indicates the lower threshold for positive signal. ****P < 0.0001, two-way ANOVA among ASTRA 4-1BB/OX-40 and ASTRA IFNγ.
