Extended Data Fig. 8: Additional in vivo data of BiKE-secreting EGFR28ΞΆ-1XX CAR-T cells together with NK cells. | Nature Biomedical Engineering

Extended Data Fig. 8: Additional in vivo data of BiKE-secreting EGFR28ΞΆ-1XX CAR-T cells together with NK cells.

From: Bispecific killer cell engager-secreting CAR-T cells redirect natural killer specificity to enhance antitumour responses

Extended Data Fig. 8

a. Schedule of the initial subcutaneous EGFR-positive solid tumour model. Tumour cells and effector cells (EGFR28ΞΆ-1XX CAR-T cells and unmodified NK cells) were injected at the time points and doses as indicated. b. Growth curves showing the time-lapse subcutaneous tumour volumes for NSG mice in different groups of Supplementary Fig. 8a (n = 5). Arrows and dashed lines indicate the time points when NK cells were adoptively transferred. Two-way analysis of variance (ANOVA) and Tukey’s multiple comparisons tests were performed and data are presented as mean values ± SD. Statistical significances for the terminal point are annotated. c. Histograms showing the expression of CD3 (left) and CD56 (right) on CAR-T cells and NK cells before being adoptively transferred. d. Histogram showing the expression of CD56 on SK-OV-3 cells before being implanted. e. Statistics on densities of tumour-infiltrating CAR-T cells (left) and NK cells (right) from the β€œBiKE- with NK” and β€œBiKE+ with NK” group in Fig. 4g (n = 5). Unpaired, two-tailed Student’s t-tests were performed and data are presented as mean values ± SD.

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