Extended Data Fig. 4: Structures of ionizable lipids in Library B and the base editing efficiency of BM cells in mice treated with different LNPs. | Nature Biomedical Engineering

Extended Data Fig. 4: Structures of ionizable lipids in Library B and the base editing efficiency of BM cells in mice treated with different LNPs.

From: In vivo genome editing of human haematopoietic stem cells for treatment of blood disorders using mRNA delivery

Extended Data Fig. 4

a. Library B contains structures of various head groups and tails in ionizable lipids. b. The top-performing ionizable lipid structures within library B were determined by analyzing the editing efficiency of BM cells in mice treated with 32 different LNP-ABE8e-PCSK9 formulations (intravenous injection, 2 mg/kg of LNP-ABE8e-PCSK9, n = 3-4 mice).

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