Extended Data Fig. 9: Loss of TrkB in mesenchymal cells worsens outcomes following sterile and infectious lung injuries.
From: STAT3–BDNF–TrkB signalling promotes alveolar epithelial regeneration after lung injury
a, H&E staining and ATS lung injury scores of tamoxifen and corn oil exposed PdgfrαCreERT2:TrkBLoxP/LoxP mice 24 hours after acid-induced lung injury (n=4 mice per group). b-d, H&E (b), PDPN (c) and Krt5 (d) staining of tamoxifen and corn oil exposed PdgfrαCreERT2:TrkBLoxP/LoxP mice 21 days after infection with PR8 influenza (n=3 mice per group). Statistical analysis was performed with a two-tailed Student’s t-test or ANOVA, where appropriate. For panels (a) and (d), data is shown as the mean +/- SEM. Statistical significance was determined with a two-tailed Student’s t-test (a) and (d). Scale bars, 100μm.
