Extended Data Fig. 4: Buffered genes and sensitive genes.
From: Decoding heterogeneous single-cell perturbation responses
a, the mean expression and PS value, calculated for each of the 10 expression quantiles, are used for fitting the Hill equation in RPL5, a buffered gene. b, The distribution of PS scores within each of the 10 expression quantiles. c-e, The Hill equation curve and the distribution of PS score for HSPA5, a sensitive gene. f, A gene (BRD4) whose expression has no correlation with PS (p = 0.41). g-j, the log fold changes of gene expressions upon perturbing genes within the same protein complex, including ribosomal subunits (g), proteosome (from genome-scale Perturb-seq in Fig. 4a; h), RNA polymerase (i) and mediator complex (j). Data in g-j come from essential gene Perturb-seq.
