Extended Data Fig. 9: Different CCDC6 functions.
From: Decoding heterogeneous single-cell perturbation responses
a-b, The two patterns of CCDC6 PSs in LV/DUO (a) and DE in transition (b) cell types. c-d, The distribution of PS across different expression quantiles of POU5F1 (PCC = 0.22 p = 7.19e-66) and SOX17 (PCC = -0.19, p = 1.75e-46), two known factors that capture continuous cell state during DE in transition. For each gene, 5 expression quantiles are used, and 1 indicates the lowest expression quantile of that gene. e-h, Additional enriched terms using Enrichr on DEGs of CCDC6 knockout. i, Flow cytometry analysis of PDX1 and HNF4A expression upon CCDC6 knockout. One representative plot of three biological replicates is shown.
