Extended Data Fig. 3: T cell development of G6pd^fl/flCd4-Cre mice.

a, Flow cytometric analysis of the percentage of CD4⁺ and CD8⁺ T cells in the thymus, spleen and lymph node of G6pd^+/+Cd4-Cre (WT) and G6pd^fl/flCd4-Cre (KO) mice (n = 3). b, Flow cytometric analysis of the cell survival of G6pd^+/+Cd4-Cre (WT) and G6pd^fl/flCd4-Cre (KO) CD8⁺ T cells stimulated in vitro for 48 hours. c, Flow cytometric analysis of the percentage of PD-1⁺Tim-3⁺ cells of Slc7a11^+/+Cd8-Cre (WT), Slc7a11^fl/+Cd8-Cre (Her), TCEP-treated WT and Her CD8⁺ T cells in exhaustion-induced condition in vitro (n = 4). Data were presented as mean ± SEM. P values were calculated by two-tailed Student’s t test (a) or one-way ANOVA with Tukey’s multiple comparisons (c). ns, no statistically significance. In a,c, n indicates the number of biological replicates. For a-c, three independent experiments were performed.

Source data