Extended Data Fig. 5: LDHB-G6PD axis in exhausted CD8+ T cells. | Nature Cell Biology

Extended Data Fig. 5: LDHB-G6PD axis in exhausted CD8+ T cells.

From: Lactate dehydrogenase B facilitates disulfidptosis and exhaustion of tumour-infiltrating CD8+ T cells

Extended Data Fig. 5

a, Native-PAGE analysis of the G6PD dimmer and G6PD monomer proteins in exhausted Ldhb+/+Cd4-Cre (WT) and Ldhbfl/flCd4-Cre (KO) CD8+ T cells. b, Heatmap of glycolysis-related metabolites in exhausted Ldhb+/+Cd4-Cre (WT) and Ldhbfl/flCd4-Cre (KO) CD8+ T cells (n = 3). c, IB analysis of LDHB protein levels in the cytosol and membrance of exhausted CD8+ T cells. Data were independently repeated 3 times (a,c). In b, n indicates the number of biological replicates. For a, c, three independent experiments were performed.

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