Extended Data Fig. 1: T cell development of Slc7a11fl/+Cd8-Cre and Slc7a11fl/+Cd4-Cre mice.
a, Flow cytometric analysis of the percentage of PD-1+Tim-3+ and IFN-γ+ CD8+ T cells in the exhaustion-induced condition in vitro in the presence of 5 mM disulfidptosis inhibitor (TCEP) at day 2, 4, 6 and 8 (n = 4). b, Flow cytometric analysis of the percentage of CD4+ and CD8+ T cells in the thymus, spleen and lymph node of Slc7a11+/+Cd8-Cre, Slc7a11fl/+Cd8-Cre and Slc7a11fl/flCd8-Cre mice (n = 3). c, Flow cytometric analysis of the percentage of CD4+ and CD8+ T cells in the thymus, spleen and lymph node of Slc7a11+/+Cd4-Cre and Slc7a11fl/+Cd4-Cre mice (n = 3). d, Flow cytometric analysis of the expressions of CD44 and CD62L in CD4+ and CD8+ T cells in the spleen of Slc7a11+/+Cd4-Cre and Slc7a11fl/+Cd4-Cre mice (n = 3). Data were presented as mean ± SEM. P values were calculated by two-tailed Student’s t test (a, c, d) or one-way ANOVA with Dunnett’s multiple comparison (b); ns, no statistically significance. In a-d, n indicates the number of biological replicates. For a-d, three independent experiments were performed.
