Extended Data Fig. 2: Carcinogens promote McSC self-renewal.
From: Antagonistic stem cell fates under stress govern decisions between hair greying and melanoma
a, Experimental scheme for DMBA treatment (upper). Macroscopic time-course images of the dorsal skin of C57BL/6 mice treated with Vehicle or DMBA at the indicated time points. Immunohistological analysis of the dorsal skin of Dct-H2B-GFP KI mice showing the distribution of GFP+ melanocytes (arrows) at 12 weeks post-onset DMBA treatment. The two panels of acetone and DMBA, respectively, show different hair follicles. Scale Bar = 60 μm. Dp; Hair depilation. b, Coat colors in the 2nd hair cycle after treatment with or without IR and UVB. Immunohistological analysis of hair follicles of Dct-LacZ Tg mice at 5 days in the 2nd hair cycle (2nd-D5). Arrowheads indicate McSCs (LacZ+ cells). The dotted lines show the Bg/sBg (Bulge/sub-Bulge). Scale Bar = 50 μm.
