Extended Data Fig. 6: Proposed annulation of phenol and the dual-oxa DA reaction model of Abx(−)F. | Nature Chemistry

Extended Data Fig. 6: Proposed annulation of phenol and the dual-oxa DA reaction model of Abx(−)F.

From: An enzymatic dual-oxa Diels–Alder reaction constructs the oxygen-bridged tricyclic acetal unit of (–)-anthrabenzoxocinone

Extended Data Fig. 6

a, Proposed reaction diagram of annulation of phenol and the dual-oxa DA reaction. Intermediate 3 either undergo a disrotatory oxa-6π electrocyclization or a 1,4-Michael addition to form compound 5. b, MS spectra of 2 and (−)-ABX in Abx(−)F assay which buffer configured with D2O and H2O. (i) MS spectra of 2 in boiled Abx(−)F and D2O buffer; (ii) MS spectra of (−)-ABX in Abx(−)F and D2O buffer; (iii) MS spectra of 2 in boiled Abx(−)F and H2O buffer; (iv) MS spectra of (−)-ABX in Abx(−)F and H2O buffer.

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