Fig. 1: C–H functionalization on-DNA.
From: On-DNA C–H functionalization of electron-rich arenes for DNA-encoded libraries
a, Rhodium-mediated C2 functionalization limited to indoles with pyrimidine as directing group. b, Lewis-acid-mediated C3 functionalization of free N–H indoles. c, Oxidative thioester synthesis between electron-rich arenes and arylthiols. d, A general C–H functionalization of arenes by means of a synthetic linchpin, and the subsequent transformations, as a strategy to expand the accessible chemical space for DEL synthesis. Depicted DNA fragment: HP–AOP–NH–. See the Methods for more details.
