Fig. 2: Scheme illustrating the FeS cluster conversions required for P- and M-cluster maturation and the central role of a K-cluster intermediate. | Nature Chemistry

Fig. 2: Scheme illustrating the FeS cluster conversions required for P- and M-cluster maturation and the central role of a K-cluster intermediate.

From: Stepwise and reversible assembly of [2Fe–2S] rhombs to [8Fe–8S] clusters and their topological interconversions

Fig. 2

a, Conversion of Fe and S into Fe2S2 clusters in NifU and NifS and their reductive fusion to Fe4S4 clusters. Here the arbitrary ligand, L, is usually a cysteinate or histidine residue, but may also refer to any other amino acid able and known to bind to Fe4S4 cofactors, for example, aspartate. b, Site differentiation and spatial merging of Fe4S4 clusters to form the K1 and K2 clusters in NifB. c, Last steps of M-cluster maturation from the Fe8S8 K-cluster intermediate, encompassing installation of the additional carbide and sulfide ligands, as well as the Mo ion. d, A hypothetically simple route from a K- (or K-like-) cluster precursor to the PNcluster via S(µ2) removal. e, Structures of the NifB K cluster proposed in refs. 16 and 15.

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