Extended Data Fig. 4: Overview of the mutational profile in each evolved replicate population.
From: Plasmid-encoded insertion sequences promote rapid adaptation in clinical enterobacteria
Summary of the genetic changes in the evolved replicate populations in the different conditions (grouped in y axis) and species (grouped in x axis). We show the number of events in each replicate population (n = 3) grouped by its strain. The label of each strain (E. coli n = 4; K. pneumoniae n = 7 and C. freundii n = 2) is indicated in the lower part of the barplot. The colors of the bars depict the different types of mutations occurring during the EE classified in NJs (IS1-mediated, Non-IS-mediated or mediated by other ISs) and SNPs (intergenic, synonymous or non-synonymous). A general increase in the number of IS1-mediated NJ events can be observed for each replicate population propagated during the EE in presence of pOXA-48 both for K. pneumoniae and C. freundii.
