Extended Data Fig. 1: Examples of genotype-by-environment interactions for gene expression and fitness.

(a, b) Relative gene expression (a) or relative fitness (b) is shown for the scenario depicted in Fig. 1c, with values for the wild-type allele shown in red and values for the alternate allele shown in blue. (c, d) Relative gene expression (c) or relative fitness (d) is shown for the scenario depicted in Fig. 1d, with values for the wild-type allele shown in blue and values for the alternate allele shown in red. In each of the four plots (a-d), lines that are not parallel indicate a genotype-by-environment interaction.