Extended Data Fig. 10: X-Y functional divergence predicts sex differences in expression and co-expression.
From: Evolutionary divergence between homologous X–Y chromosome genes shapes sex-biased biology
a. Figure 5a with tissue specific regression lines. b. Enrichment results between overall asymmetric coupling and sex-biased co-expression (Methods). OR = odds ratio. c. Mean scaled co-expression values between all pairs of X-biased genes and Y-biased genes in each tissue in males (green) versus females (yellow) (tissue-specific results in Supplementary Table 23). d. Data used for Fig. 5d. All pair-level asymmetric coupling values for N = 24 ASD risk genes with significant overall asymmetric coupling (CLIP padj<0.05) in BA24 are shown (see right column for direction of overall asymmetric coupling; ASD risk genes are separated by functional category). Only significant pair-level values (CLIP padj<0.05) are included in Fig. 5d, and in this figure they are outlined in black.
