Extended Data Fig. 3: Volcano plot analysis of gene expression of M. jannaschii transcriptomes in MMC Medium at 25 and 80 °C (Experiments 5c, d, Supplemental Table 1). | Nature Ecology & Evolution

Extended Data Fig. 3: Volcano plot analysis of gene expression of M. jannaschii transcriptomes in MMC Medium at 25 and 80 °C (Experiments 5c, d, Supplemental Table 1).

From: Simulated early Earth geochemistry fuels a hydrogen-dependent primordial metabolism

Extended Data Fig. 3

Of all significant genes (P = 0.05, one-sided t-test), 96 are overexpressed at 80 °C (dark blue, Experiment 5c) compared to 25 °C. 241 genes were down regulated at 80 °C compared to 25 °C (light blue, Experiment 5 d). The vertical line separates expressed genes that either increased or decreased in rank in the MMC medium, the dotted horizontal line represents the P-value cutoff for determining statistical significance (one-sided T-test). Of all overexpressed genes, two are part of the methanogenic acetyl CoA pathway: methyl coenzyme M reductase system component A2 (atwA) and NADPH-dependent F420 reductase (npdG).

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