Extended Data Fig. 7: Growth rates of consecutive mutants within plateaus.
From: Cryptic phenotypic variation emerges rapidly during the adaptive evolution of a carbapenemase
(a) Optical density changes over 12 h of growth. The black line represents the strain with wild-type KPC-2, gray lines represent earlier plateau strains, and colored lines represent subsequent strains. (b) Boxplot summarizing maximum growth rates from the growth curves above. X-axis labels, excluding the control strain, consist of a bottom label indicating the evolutionary line (as in Table S2) and a top label indicating which round the isolate was taken from (round 2: R2; round 3: R3; round 4: R4). Following R’s default convention, boxes span the first (Q1) to third (Q3) quartiles, central lines mark the median, and whiskers reach the most extreme points within 1.5 times the interquartile range.
