Fig. 7: Nanostar sieving for liquid-phase peptide synthesis. | Nature Energy

Fig. 7: Nanostar sieving for liquid-phase peptide synthesis.

From: A hybrid modelling approach to compare chemical separation technologies in terms of energy consumption and carbon dioxide emissions

Fig. 7

a,b, Process schematic (a) and original versus proposed chemical structures (b). Predicted rejections (R′) were estimated using the weighted average of the machine learning-predicted rejections on DMF–DuraMem 300 and MeTHF–polybenzimidazole (PBI). Fmoc, fluoren-9-ylmethyloxycarbonyl. c, PCA–t-SNE chemical space visualization with the solutes S13–S22 highlighted. d, log rejection selectivity (\(\log \varphi\), where \(\varphi\) = (1 − Rimpurity)/(1 − Rnanostar)) between nanostars S13–S15 and impurities S16–S18 (left y axis). Measured nanostar rejection in NMP–THF (NMP, N-methyl-2-pyrrolidone; THF, tetrahydrofuran; 65:35, v/v%) with a crosslinked PBI membrane at 20 bar and 20 °C in a cross-flow configuration (right y axis). Measured rejections are denoted with R. Structures of S19–S22 are detailed in Fig. 8.

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