Extended Data Fig. 3: Effect of collagen pre-alignment on fibroblast morphology. | Nature Materials

Extended Data Fig. 3: Effect of collagen pre-alignment on fibroblast morphology.

From: Tension anisotropy drives fibroblast phenotypic transition by self-reinforcing cell–extracellular matrix mechanical feedback

Extended Data Fig. 3

Representative image selected from over 30 cells imaged in a collagen ECM with an initial cell density of 2×104 cells/ml. When cultured within a pre-aligned collagen matrix, fibroblasts predominantly aligned with the collagen fibres and elongated in that direction. Green: collagen (confocal reflectance); Blue: nuclei (DAPI); Orange: tubulin. Scale bar: 50 μm.

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