Extended Data Fig. 6: Metabolic and secretory analyses in response to tissue stiffening. | Nature Materials

Extended Data Fig. 6: Metabolic and secretory analyses in response to tissue stiffening.

From: Local photocrosslinking of native tissue matrix regulates lung epithelial cell mechanosensing and function

Extended Data Fig. 6

a. Quantification of extracellular lactate and glucose concentrations in 24 hours culture of murine CTRL and STIFF PCLS (day 3-4, n = 3 mice, ****p<0.0001 by two-tailed unpaired Mann Whitney test). b. Quantification of extracellular cytokine concentrations (Interleukin-1 beta (IL-1β), Interleukin-6 (IL-6), Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Interferon-Gamma Inducible Protein 10 (IP-10), Granulocyte Colony-Stimulating Factor (G-CSF), Tumor Necrosis Factor-alpha (TNF-α), S100 calcium binding protein A8 (S100A8), Macrophage inflammatory protein 2 (MIP-2), Macrophage Inflammatory Protein 3 (MIP-3), and Monokine Induced Gamma Inteferon (MIG) in 24 hours culture of murine CTRL and STIFF PCLS (day 4-5, n = 3 mice, p as indicated, ns= not significant by two-tailed unpaired Mann Whitney test). For all box plots, the centre line represents the median, the box limits are upper and lower quartiles, and the whisker limits are the minimum and maximum points on the plots.

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