Extended Data Fig. 1: NLRC4 is required to restrict microbial spread during an oral sub-lethal but not an oral lethal infection with S. Typhimurium. | Nature Microbiology

Extended Data Fig. 1: NLRC4 is required to restrict microbial spread during an oral sub-lethal but not an oral lethal infection with S. Typhimurium.

From: Modifying bacterial flagellin to evade Nod-like Receptor CARD 4 recognition enhances protective immunity against Salmonella

Extended Data Fig. 1

a, Wild-type and nlrc4−/− mice were challenged orally with 4.4 × 109 CFU S. Typhimurium M525P to establish a sub-lethal infection and microbial burden was determined in the spleen and liver at 5 days (n = 6 for wild-type and Nlrc4−/−) and 14 days (n = 7 for wild-type and n = 6 for Nlrc4−/−) post-challenge. b, Wild type and Nlrc4−/− mice were challenged orally 8 × 108 CFU S. Typhimurium SL1344 to establish a lethal infection and microbial burden was determined in the spleen and liver at 4 days post-challenge. Each symbol represents one mouse and horizontal lines delineate the mean. Statistical significance was calculated by 2-way ANOVA followed by Sidak’s multiple comparisons test for a and two-tailed Mann Whitney test for b. Data are representative of two independent experiments.

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