Extended Data Fig. 9: R. delemar toxin is expressed in lung tissue collected from a mucormycosis patient but not in lung samples from an aspergillosis patient.
From: Mucoricin is a ricin-like toxin that is critical for the pathogenesis of mucormycosis
H&E staining of lung tissues from mucormycosis a, or aspergillosis b, patients showing broad aseptate hyphae with angioinvasion (Mucorales) and thinner septated hyphae of Aspergillus. Scale bar is 10 μm. Box magnification 1400 X. Staining of a mucormycosis c, or aspergillosis d, patient lungs using IgG anti-toxin (green colour). Mucorales or Aspergillus hyphae are shown in yellow (stained with calcofluor white) and nuclei are shown in magenta. R. delemar toxin staining is shown in association with hyphae (grey arrow) and released in the tissue (white arrow). Scale bar is 10 μm in all micrographs.
