Extended Data Fig. 1: Predictions of SCFA production using 16S amplicon sequencing or shotgun metagenomic sequencing data show concordance.
Data from Study C included 16S amplicon sequencing as well as shotgun metagenomic sequencing. (a-b) Predictions for butyrate and propionate between models summarized to the genus level from 16S amplicon sequencing data and shotgun metagenome data (butyrate: Pearson’s Correlation r = 0.90, p = 9.9e-11; propionate: Pearson’s Correlation r = 0.52, p = .0058). Pearson’s correlation r value and associated two-tailed p-value were calculated across all points. The dashed black line denotes a linear regression line and the gray area denotes the 95% confidence interval of the regression line. (c-d) Predictions for butyrate and propionate from models built using shotgun metagenome data at the genus level and species level (butyrate: Pearson’s Correlation r = 0.72, p = 2.1-5; propionate: Pearson’s Correlation r = 0.33, p = .089). Pearson’s correlation r value and associated two-tailed p-value were calculated across all points. The dashed black line denotes a linear regression line and the gray area denotes the 95% confidence interval of the regression line.
