Extended Data Fig. 3: MCMMs built from shotgun metagenomic sequencing data perform better when constructed at the species level, as compared to the genus level.
MCMMs from ex vivo studies A, C and D were constructed at the (a) genus (butyrate: Pearson’s Correlation r = 0.46, p =3.0e-4; propionate: Pearson’s Correlation r = 0.33, p = .011) and (b) species level (butyrate: Pearson’s Correlation r = 0.51, p = 7.1e-5; propionate: Pearson’s Correlation r = 0.45, p = 5.8e-4). Prediction production rate of butyrate and propionate more closely matched measured production rate in the species level model as compared to the genus level model. Pearson’s correlation r value and associated two-tailed p-value were calculated across all points. The dashed black line denotes a linear regression line and the gray area denotes the 95% confidence interval of the regression line. Color encoding indicates the specific study from which each point originates.
