Extended Data Fig. 3: HI titres to past isolates against year of birth.
From: Immune imprinting in early life shapes cross-reactivity to influenza B virus haemagglutinin
(a) Log2 HI titres to different isolates against year of birth separated by IBV lineage and dataset. The lines represent estimated mean HI titres from generalized additive models (GAMs). (b) Estimated mean HI titres against past isolates from each lineage that circulated prior to sample collection, against the year of birth for each participant. (c) Comparison of the three datasets for HI against each lineage by year of birth. The data is the same as in (B) but overlaid for three datasets per lineage. For (B) and (C) The lines represent the estimated mean HI titre from generalized additive models (GAMs) with shading representing 95% CIs, accounting for repeated measurements on each individual by specifying a random effect.
