Extended Data Fig. 8: Comparison of iRep in IgA+ vs. Native Fractions Across Phyla and Genera.

For each phylum (A) and genus (B) with at least 5 measurements, the difference in iRep in IgA+ vs. native fractions of all species detected within that phylum or genus. Negative values indicate IgA is associated with reduced replication rates. P-values from post hoc two-sided pairwise test for multiple comparisons of mean rank sums (Dunn’s test). For Firmucutes_A, Bacteroidota, Firmicutes, and Actinobacteria, n = 144, 32, 10, and 8, respectively. All exact p-values > 0.05 are shown in the figure. For genera, in order from top to bottom, n = 5, 6, 19, 8, 6, 5, 5, 6, 5, 7, and 6. Boxplots show the minimum and maximum (whiskers), median (center line), and interquartile range (box bounds); whiskers extend up to 1.5 times the interquartile range.