Extended Data Fig. 6: Influence of P2Y11 agonists on HeLa cytoskeleton and the influence of HD5 on caspase activities of HeLa cells.
a, b, Effects of ATPγs and NAD+ on filopodia generation capacity and bacterial invasion efficiency (n = 8). In a, F-actin is red and nuclei are blue (DAPI), the bar represents 10 μm; in b, Data are presented as mean±s.d. c, In non-infected (left panel) and infected (right panel) conditions, the caspase activities (Caspase 3/7) of HeLa cells were assessed in the presence or absence of 4 μM HD5 (n = 3). Significance between indicated groups was calculated using a one-way ANOVA (Dunnett’ s multiple comparison Test for b and Tukey’ s multiple comparison for c), and indicated as the p values. ns, not significant, *p < 0.05, **p < 0.01, ***p < 0.001 and ****p < 0.0001. All results are representative of at least three independent experiments.
