Fig. 1: Study overview. | Nature Microbiology

Fig. 1: Study overview.

From: Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans

Fig. 1

a, Pictorial representation of the YF17D and JE/YF17D vaccine constructs. JE/YF17D is constructed by splicing the prM and E genes of the Japanese encephalitis SA 14-14-2 virus (represented in blue) into the C and NS backbone of YF17D (represented in red). b, Overall study design. A total of 34 Orthoflavivirus-naive healthy volunteers were randomized to receive either JE/YF17D vaccination on day 0 followed by YF17D challenge on day 28 (arm 1) or YF17D vaccination on day 0 followed by JE/YF17D challenge on day 28 (arm 2) and followed up until day 56. c, CONSORT diagram showing the flow of study participants through the randomized–controlled trial. D, day. Panel b created by BioRender.com.

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