Extended Data Fig. 6: Kinetics of T cell response after heterologous challenge infection. | Nature Microbiology

Extended Data Fig. 6: Kinetics of T cell response after heterologous challenge infection.

From: Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans

Extended Data Fig. 6

Log2 fold-change of magnitude of T cell response against E homologous to the challenge virus (top row), C (second row), NS3 (third row) and NS5 (last row), in vaccinees on days 4, 7, 10, 14 and 28 post-challenge, compared to baseline levels on day of challenge. Dotted line indicates no change from baseline. a-d, Vaccinees with no detectable RNAemia and absence of seroconversion post-challenge (n = 5). e-h, Vaccinees with no detectable viremia but who seroconverted post-challenge (n = 3). i-l, Vaccinees with detectable RNAemia post-challenge (n = 25). Each line with connected dots represents an individual participant.

Back to article page