Fig. 5: Higher C-specific T cell response is associated with post-challenge aviraemia. | Nature Microbiology

Fig. 5: Higher C-specific T cell response is associated with post-challenge aviraemia.

From: Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans

Fig. 5

a–p, T cell responses against C (a–d), NS3 (e–h), NS5 (i–l) and the sum of the responses to all three proteins (m–p), on days 14, 28, 32 and 35, were compared between vaccinees with and without detectable RNAaemia post-challenge. The open black circles represent vaccinees with detectable RNAaemia post-challenge (n = 25), while the red dots represent those with undetectable RNAaemia (n = 8). The horizontal black bars represent the mean. q,r, ROC curves for comparing vaccinees with and without detectable RNAaemia post-challenge based on the day 14 (q) and day 28 (day of challenge) (r) T cell response against C. P values were calculated with a two-tailed unpaired Mann–Whitney U test. NS, not significant.

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