Extended Data Fig. 4: Association between innate immune response or binding antibodies and post-challenge viremia. | Nature Microbiology

Extended Data Fig. 4: Association between innate immune response or binding antibodies and post-challenge viremia.

From: Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans

Extended Data Fig. 4

a,b, Heat map showing gene expression profiles of YF17D vaccinees on day 28 (day of JE/YF17D challenge) (a) and (b) day 29 (one day post-JE/YF17D challenge) from the nCounter human immunology panel. Z-scores of log2 counts are displayed. c,d, Correlation between anti-YF NS1 (c) and anti-JE E (d) antibody levels on day 28 post-YF17D vaccination (day of JE/YF17D challenge), and viral RNA levels post-JE/YF17D challenge. e,f, Heat map showing gene expression profiles of JE/YF17D vaccinees on day 28 (day of YF17D challenge) (e) and day 29 (one day post-YF17D challenge) (f) from the nCounter human immunology panel. Z-scores of raw log2 counts are displayed. g,h, Correlation between anti-YF NS1 (g) and anti-YF E (h) antibody levels on day 28 post-JE/YF17D vaccination (day of YF17D challenge), and viral RNA levels post-YF17D challenge. P values calculated with two-tailed Spearman’s correlation.

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