Extended Data Fig. 6: Humoral immune responses induced by PROTAR vaccines in adult mice. | Nature Microbiology

Extended Data Fig. 6: Humoral immune responses induced by PROTAR vaccines in adult mice.

From: Proteolysis-targeting influenza vaccine strains induce broad-spectrum immunity and in vivo protection

Extended Data Fig. 6

a-b, Titers of NT (a) and HI (b) antibodies in sera of C57BL/6 J mice at day 21 post-vaccination with 105 TCID50 of indicated vaccines (n = 5 mice per group). Data are shown as means ± s.d.; one-way ANOVA with Dunnett’s multiple comparisons test; black P values indicate the statistical comparison to Vehicle group; orange P values indicate the statistical comparison to IIV group; red P values indicate the statistical comparison to M1-PTD. c-d, Titers of IgG antibodies against viral surface protein HA (c) and internal conserved protein NP (d) in sera of C57BL/6 J mice at day 21 post-vaccination with 105 TCID50 of indicated vaccines (n = 5 mice per group). Data are shown as means ± s.d.; one-way ANOVA with Dunnett’s multiple comparisons test; black P values indicate the statistical comparison to Vehicle group; orange P values indicate the statistical comparison to IIV group; blue P values indicate the statistical comparison to CAIV group; red P values indicate the statistical comparison to M1-PTD.

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