Extended Data Fig. 8: T cellular immune responses induced by PROTAR vaccines in adult mice. | Nature Microbiology

Extended Data Fig. 8: T cellular immune responses induced by PROTAR vaccines in adult mice.

From: Proteolysis-targeting influenza vaccine strains induce broad-spectrum immunity and in vivo protection

Extended Data Fig. 8

a, Viral M1 antigen peptide-specific T cell responses in lungs of C57BL/6 J mice at day 7 post-vaccination with 105 TCID50 of indicated vaccines (n = 5 mice per group), measured by enzyme-linked immunospot (ELISpot) assay. M1128-135 (MGLIYNRM) antigen peptide was used as the stimuli. Data are shown as means ± s.d.; one-way ANOVA with Dunnett’s multiple comparisons test; black P values indicate the statistical comparison to Vehicle group; orange P values indicate the statistical comparison to IIV group; blue P values indicate the statistical comparison to CAIV group; red P values indicate the statistical comparison to M1-PTD. b-c, Viral NP antigen peptide-specific T cell responses in lungs (b) and spleens (c) of C57BL/6 J mice at day 7 post-vaccination with 105 TCID50 of indicated vaccines (n = 5 mice per group), measured by enzyme-linked immunospot (ELISpot) assay. NP366-374 (ASNENMETME) antigen peptide was used as the stimuli. Data are shown as means ± s.d.; one-way ANOVA with Dunnett’s multiple comparisons test; black P values indicate the statistical comparison to Vehicle group; orange P values indicate the statistical comparison to IIV group; blue P values indicate the statistical comparison to CAIV group; red P values indicate the statistical comparison to M1-PTD.

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