Fig. 5: Cross-resistance of CD388-selected NA variants to OST and ZAN.
From: Drug–Fc conjugate CD388 targets influenza virus neuraminidase and is broadly protective in mice
a,b, Fold change of a plaque-purified clone isolated at passage 10 versus parental strains by EC50 [nM] to CD388-selected NA variants S231R (S247R) in A/WSN/1933 (H1N1) (a) or A246V in combination with HA N113H/T453I in A/Victoria/3/75 (H3N2) (b) for CD388, OST and ZAN in cell-based PRA. EC50 values were derived from 3 independent PRA replicates.
