Extended Data Fig. 1: The NA tetramer with tetrameric ZAN.
From: Drug–Fc conjugate CD388 targets influenza virus neuraminidase and is broadly protective in mice
Crystal structure of tetrameric ZAN (green) complexed to an NA tetramer (PDB code 3TI5) from A/California/04/2009 H1N1. The C7 position on ZAN that was chosen for attachment to the Fc carrier (via an NHS ester) in the work presented here is highlighted. C7 on ZAN is solvent exposed and unencumbered sterically, allowing conjugation to the C7 position with minimal influence on binding affinity to NA.
