Extended Data Fig. 6: Model of ATG5 activity in neutrophils. | Nature Microbiology

Extended Data Fig. 6: Model of ATG5 activity in neutrophils.

From: ATG5 suppresses type I IFN-dependent neutrophil effector functions during Mycobacterium tuberculosis infection in mice

Extended Data Fig. 6

Model depicting how ATG5 functions in neutrophils to regulate type I IFN-induced NET release and swarming. Mtb infection in neutrophils activates type I IFN signaling and PAD4-mediated histone citrullination, where type I IFN signaling promotes the extracellular release of NETs3. ATG5 functions downstream of type I IFN signaling to suppress type I IFN-induced PAD4-mediated histone citrullination and CXCL2 production during Mtb infection. ATG5 also limits histone citrullination in bystander neutrophils in culture with GFP-Mtb+ neutrophils. Created with BioRender.com.

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