Extended Data Fig. 5: GMT of HAI cross-reactivity at different years between isolations stratified by of AA substitutions potential N-linked glycosylation sites.
From: Breadth of influenza A antibody cross-reactivity varies by virus isolation interval and subtype
Data from the Crick’s reports and GISAID were used. Dots, solid lines, and shaded areas represent the mean titer and 95% confidence intervals from the log-linear regression. Each panel represents an antigenic site, with colours denoting distinct combinations of specific AA sequences that could potentially transform into glycosylation sites between the immunizing and tested viruses at that location. For instance, beginning at site 45, ‘NSS +/-‘ indicates the presence of asparagine-serine-serine in the immunizing virus but not in the tested virus. (a) position 45. (b) position 63. (c) position 122. (d) position 126. (e) position 133. (f) position 144. (g) position 158. (h) position 165. (i) position 246.
