Extended Data Fig. 6: Longitudinal A(H3N2) antibody landscape changes after infections or vaccinations.
From: Breadth of influenza A antibody cross-reactivity varies by virus isolation interval and subtype
Panels a-c use data from Fonville et al.5, with 12 A(H3N2) PCR-positive individuals (aged 14-72 years). Panels d-f use secondary antisera data from Hinojosa et al.24, with children aged 7-17 years. The study includes 31 unvaccinated children receiving vaccines in the 2015/16 season and 41 children vaccinated in both 2014/15 (A/Texas/50/2012) and 2015/16 (A/Switzerland/9725193/2013) seasons. Panels g-i use secondary antisera data from Ertesvåg et al.25, with children aged 3–17 years. The study includes 42children receiving vaccines in 2012/13 or 2013/14 seasons, with vaccine strain of A/Victoria/261/2011 for both seasons. (a) Average landscapes before and after PCR-positive results, sorted by virus isolation year. Vertical dashed lines indicate PCR-positive result years (2008–2011). Fold changes were calculated using antisera from PCR-positive year and the previous year (same for panel d and g). (b) Aligned landscapes before and after PCR-positive results, sorted by years between virus isolation and PCR-positive results. Yellow shade (based on Fig. 4 estimates) represents expected time span of HAI titers at least 40 after a single infection (same for panel e and h). (c) Aligned landscapes before and after PCR-positive results, sorted by years between virus isolation and first virus encountered (assumed at age 4). (d) Average landscapes before and after vaccinations, sorted by virus isolation year and vaccine history. (e) Aligned landscapes before and after vaccinations, sorted by years between virus isolation and PCR-positive results, stratified by vaccine history. (f) Aligned landscapes before and after vaccinations, sorted by years between virus isolation and first virus encountered, stratified by vaccine history. (g) Average landscapes before and after vaccinations, sorted by virus isolation year. (h) Aligned landscapes before and after vaccinations, sorted by years between virus isolation and PCR-positive results. (i) Aligned landscapes before and after vaccinations, sorted by years between virus isolation and first virus encountered.
