Extended Data Table 3 The quantity of potential AMPs identified among NRSPDs

NRSPDs	Total	m_AMPs^0.5	m_AMPs^0.5_nontox^0.5 (Candidate Pool)	m_AMPs^0.5_nontox^0.5_rs^0.88	m_AMPs^0.9	m_AMPs^0.9_nontox^0.5	m_AMPs^0.9_nontox^0.5_rs^0.88
8-10 AAs	90,387,710	35,542,378 (39.3%)	23,854,081 (26.4%)	389	12,643,211 (3.1%)	8,486,665 (9.4%)	149
11-15 AAs	114,045,664	40,651,897 (35.6%)	27,794,568 (24.3%)	13	13,522,243 (3.3%)	9,241,008 (8.1%)	5
16-20 AAs	83,547,524	21,765,145 (26.1%)	14,686,277 (17.6%)	0	6,174,054 (1.5%)	4,164,267 (5.0%)	0
21-25 AAs	67,076,273	13,897,562 (20.7%)	9,585,442 (14.3%)	0	3,784,657 (0.9%)	2,611,351 (3.9%)	0
26-30 AAs	55,135,106	9,548,829 (17.3%)	6,774,560 (12.3%)	0	2,564,112 (0.6%)	8,486,665 (15.4%)	0
Total	410,192,277	121,405,811 (29.6%)	82,694,928 (20.2%)	402	38,688,277 (9.4%)	26,322,225 (6.4%)	154

Note: m_AMPs^0.5: AMPSorter threshold of 0.5;
m_AMPs^0.5_nontox^0.5: AMPSorter threshold of 0.5 and BioToxiPept threshold of 0.5;
m_AMPs^0.5_nontox^0.5_rs^0.88: AMPSorter threshold of 0.5, BioToxiPept threshold of 0.5, and QSAR threshold of 0.88;
m_AMPs^0.9: AMPSorter threshold of 0.9;
m_AMPs^0.9_nontox^0.5: AMPSorter threshold of 0.9 and BioToxiPept threshold of 0.5;
m_AMPs^0.9_nontox^0.5_rs^0.88: AMPSorter threshold of 0.9, BioToxiPept threshold of 0.5, and QSAR threshold of 0.88.

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