Extended Data Table 4 The quantity of potential AMPs identified among GNRSPDs

From: A generative artificial intelligence approach for the discovery of antimicrobial peptides against multidrug-resistant bacteria

GNRSPDs

Total

g_AMPs0.5

g_AMPs0.5_nontox0.5 (Candidate Pool)

g_AMPs0.5_nontox0.5_rs0.88

g_AMPs0.9

g_AMPs0.9_nontox0.5

g_AMPs0.9_nontox0.5_rs0.88

Prefix-A

771

449 (58.2%)

369 (47.9%)

0

229 (2.9%)

183 (23.7%)

0

Prefix-F

791

602 (76.1%)

531 (67.1%)

11

382 (4.9%)

342 (43.2%)

5

Prefix-G

790

675 (85.4%)

443 (56.1%)

2

489 (6.3%)

320 (40.5%)

2

Prefix-I

779

568 (72.9%)

526 (67.5%)

2

314 (4.0%)

289 (37.1%)

1

Prefix-K

787

678 (86.1%)

528 (67.1%)

3

514 (6.6%)

401 (51.0%)

2

Prefix-L

762

575 (75.5%)

514 (67.5%)

6

342 (4.4%)

295 (38.7%)

3

Prefix-R

760

631 (83.0%)

529 (69.6%)

10

458 (5.9%)

384 (50.5%)

7

Prefix-S

792

658 (83.1%)

367 (46.3%)

0

453 (5.8%)

258 (32.6%)

0

Prefix-V

790

457 (57.8%)

401 (50.8%)

3

210 (2.7%)

182 (23.4%)

2

Prefix-W

776

645 (83.1%)

528 (68.0%)

25

508 (6.5%)

415 (53.5%)

20

Total

7,798

5,938 (76.1%)

4,736 (60.7%)

62

3,899 (50.0%)

3,069 (39.4%)

42

  1. Note: g_AMPs0.5: AMPSorter threshold of 0.5;
  2. g_AMPs0.5_nontox0.5: AMPSorter threshold of 0.5 and BioToxiPept threshold of 0.5;
  3. g_AMPs0.5_nontox0.5_rs0.88: AMPSorter threshold of 0.5, BioToxiPept threshold of 0.5, and QSAR threshold of 0.88;
  4. g_AMPs0.9: AMPSorter threshold of 0.9;
  5. g_AMPs0.9_nontox0.5: AMPSorter threshold of 0.9 and BioToxiPept threshold of 0.5;
  6. g_AMPs0.9_nontox0.5_rs0.88: AMPSorter threshold of 0.9, BioToxiPept threshold of 0.5, and QSAR threshold of 0.88.