Extended data Fig. 1: Selective biodistribution of P-G3 to visceral fat.
From: Selective targeting of visceral adiposity by polycation nanomedicine
a, Cy5 signal quantification of different tissues in Fig. 1a. b, Tissue distribution quantification of different materials in Fig. 1h–i: vehicle (n = 2), all the treatment groups (n = 2). c–e, 200 μg Cy5-labled P-G3 was i.p. injected into chow-fed mice and fluorescent signals were determined using an IVIS Optical Imager. PBS was used as vehicle control. c, Signal in live animals during the treatment at indicated time; imaging of tissues from mice sacrificed at 56-hr post-injection (d) and quantification of fluorescent signals, vehicle (n = 1), P-G3 group (n = 3). Data were represented as mean ± s.e.m. (e). f, 200 μg Cy5-labled P-G3 was injected into HFD-fed mice comparing different delivery routes, and Cy5 signal in tissues was determined at 24-hr post-injection. The unit of fluorescent scale bar is photons/sec/cm2/sr.
