Extended data Fig. 2: The anti-obesity effect of P-G3 is reproduced in diet-induced obese female mice but not in lean animals. | Nature Nanotechnology

Extended data Fig. 2: The anti-obesity effect of P-G3 is reproduced in diet-induced obese female mice but not in lean animals.

From: Selective targeting of visceral adiposity by polycation nanomedicine

Extended data Fig. 2

a–d, 17-wk-old female C57BL/6J mice were intraperitoneally treated with P-G3 (10 mg/kg.BW) or vehicle twice weekly for 6 weeks since the beginning of HFD feeding. Data were represented as mean ± s.e.m. (n = 5, 6). Statistical significance was calculated via 2-tailed Student’s t-test. a, Body weight curve. b, c, Changes of fat mass (b) and lean mass (c) during P-G3 treatment determined by Echo-MRI. d, Organ weights at sacrifice. e–g, 6-wk-old male mice were fed on chow diet and received twice weekly P-G3 (10 mg/kg.BW) intraperitoneally for 6 weeks. Data were represented as mean ± s.e.m. (n = 5, 5). Statistical significance was calculated via 2-tailed Student’s t-test. e, Body weight curve. f, Body composition determined by EchoMRI. g, Organ weights at sacrifice.

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