Extended Data Fig. 5: Systemic i.v. administration of Ti2NX nanodots eliminated established tumours.
From: Autophagosomes coated in situ with nanodots act as personalized cancer vaccines
a, An orthotopic luc-4T1 murine breast cancer model was established; Ti2NX nanodot injections during intravenous administration were administered on day 0, 3, and 6; in the intratumoural injection group, three tumour-bearing mice were treated with a single injection, while the 4th received a second injection on the 6th day. b, Tumour growth curves after different treatments in the 4T1 tumour model, n = 4. c, In vivo bioluminescence imaging of orthotopic 4T1 murine breast cancer, n = 4. d, Schematic illustration of the experimental design. The 4T1 lung metastatic tumour model was established. e, Quantification of 4T1 metastatic nodules in the lungs; n = 4 mice per group. P = 5 × 10−5. f, Representative photograph of lungs collected from mice after different treatments. g, Images of H&E-stained lungs collected from mice after different treatments; n = 4 mice per group. Error bars represent the mean ± s.d. The data in (e), were analysed by two-tailed, unpaired Student’s t test.
