Extended Data Fig. 6: Effect of the temperature correction on the rate constants reported in the single-molecule literature for the dissociation of ACE2 from the wild-type RBD.
From: Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection
Experiments involved either RBD alone, S1 alone, or spike trimers (see Table Supplementary Table 6 for numerical values). (a) Data issued from acquisitions realized at various temperatures \({T}_{{meas}}\) (in both logarithmic and linear scales, ± s.e. for the Saha et al. data). (b) Same data extrapolated at 22 °C using the Arrhenius law and an activation energy equal to 90 kJ mol−1. (c) Same extrapolation but with an activation energy equal to 125 kJ mol−1.
