Extended Data Fig. 7: Representative images of an HS-AFM video showing binding of an ACE2 to S trimer \({\mathbf{S}}_{\mathbf{Wuhan}}^{\mathbf{f-}}\). | Nature Nanotechnology

Extended Data Fig. 7: Representative images of an HS-AFM video showing binding of an ACE2 to S trimer \({\mathbf{S}}_{\mathbf{Wuhan}}^{\mathbf{f-}}\).

From: Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection

Extended Data Fig. 7

Free ACE2 is indicated by a cyan arrowhead and bound ACE2 (that cannot be distinguished from the RBD to which it is bound) by green ones. The spike stalk region is indicated by white and open RBDs by yellow ones. Timestamps are displayed in the top right corner of each image. On the left, a simulated AFM image is generated from the cryo-EM structure of one ACE2 bound to one S trimer (PDB: 7knb) to illustrate the relative positioning of ACE2 and RBD in the experimental observation.

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