Extended Data Fig. 2: Conformational dynamics of RBD opening and closing in \({\mathbf{S}}_{\mathbf{Wuhan}}^{\mathbf{f-,2C,2P}}\).
From: Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection
(a) Relative occupancy histogram (mean ± s.e.m., blue bars) and associated fits to the binomial distribution (red lines) for the four \({S}_{i}\) states, i indicating the number of opened RBDs. (b) Transition density plot (TDP) showing the fraction of transition events between the different states. (c) Distributions of the \({\Delta t}_{i,\;j}\) dwell times for the four most populated \({S}_{i}\) to \({S}_{j}\) transitions. Red lines show the global exponential fits used to extract the \({\tau }_{i,\;j}\) decays (see Extended Data Table 1 for results and Supplementary Table 2 for statistics).
