Extended Data Table 2 Energy landscape parameters for the dissociation reaction between the ACE2 and RBD, either isolated or embedded within a S trimer

From: Modulation of SARS-CoV-2 spike binding to ACE2 through conformational selection

  1. \({k}_{D}\) corresponds to the dissociation rate constants extrapolated at zero force, \({x}^{\ddagger }\) to the distance to the transition state, \({\Delta G}^{\ddagger }\) and \({E}_{D}\) to the free and activation energies, respectively. HS-FS experiments were performed at room temperature in PBS pH 7.4 and MT experiments between 25 and 37 °C in 10 mM Na-HEPES pH 7.4, 150 mM NaCl, 0.1 % Tween 20 and 0.5 mg/mL BSA.
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