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Interferometric microscopy

Imaging single ion channels via their Rayleigh scattering

The fast and convenient study of ion channels in cells continues to pose challenges. Interferometric scattering microscopy delivers robust signals from single channels, paving the way for label-free investigation of their function in live cells.

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Fig. 1: EM-iSCAT measurements in a nutshell.

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Correspondence to Vahid Sandoghdar.

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Sandoghdar, V. Imaging single ion channels via their Rayleigh scattering. Nat. Photon. 19, 779–780 (2025). https://doi.org/10.1038/s41566-025-01727-9

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